• Amy Schumer recently shared she had quit Wegovy due to side effects like nausea.
• However, Schumer said she was “having a really good experience” with Mounjaro, such as improved menopause symptoms and libido.
• Experts say it’s common for people to have side effects with GLP-1s.
• If you can’t tolerate a GLP-1 drug, your doctor might recommend switching to a different weight loss medication.

Writer, actress, and stand-up comedian Amy Schumer recently took to Instagram to discuss her experiences with the GLP-1 drugs Wegovy (semaglutide) and Mounjaro (tirzepatide).

While appearing to be driving through stop-and-go traffic, which she noted at one point was “completely unsafe,” Schumer said she wanted to “keep it a hundred” with her fans regarding her weight-loss journey.

After quipping that she’s “your favorite comedian with no top lip,” the star revealed on March 21 that she had used Wegovy three years prior but had experienced intolerable side effects.

“I was like puking, I couldn’t handle it,” she related.

Schumer then went on to describe how she had more recently used the telehealth provider Midi Health to receive hormone treatment for perimenopause as well as being prescribed Mounjaro for weight loss.

The actress added this combination of medications was working well for her.

“My symptoms of being in perimenopause have disappeared. My hair is fuller, my skin is better, I have more energy,” said Schumer.

“I want to get down more,” she added, referring to the positive effect on her libido. “So, yeah, that’s been great. Mounjaro’s been great,” Schumer said.

She further explained to viewers that Mounjaro is generally covered by insurance unless you have a diagnosis of diabetes or “severe obesity, which most of the Internet thinks I have.”

Schumer then closed out the video by saying she is “having a really good experience” and “wanted to keep it real,” adding that she liked Midi Health so much that she decided to invest in the company.

Why did Schumer do better on Mounjaro than Wegovy?

Meghan Garcia-Webb, MD, obesity medicine doctor at Weight Medicine MD, told Healthline it’s not uncommon for people to have significant side effects from one GLP-1 medication but not another.

“It is hard to predict who will be able to tolerate them and who won’t,” she said, “although people who already struggle with gastrointestinal health issues may find these medications make them worse.”

Garcia-Webb added that clinically, she does find that people often have fewer side effects on Mounjaro than on Wegovy. However, she said some research suggests the side effect profiles are similar.

Novo Nordisk states that common side effects with Wegovy include:

• nausea
• diarrhea
• vomiting
• constipation
• abdominal pain
• upset stomach
• headache
• tiredness
• dizziness
• bloating
• belching
• low blood sugar (if you have type 2 diabetes)
• gas
• stomach flu
• heartburn
• runny nose or sore throat

On the other hand, Eli Lilly lists nausea, diarrhea, decreased appetite, vomiting, constipation, indigestion, and abdominal pain as Mounjaro’s most common side effects.

Garcia-Webb said it also depends on how long people are able to wait for side effects to subside.

“Oftentimes, side effects are worse in the beginning and when titrating up on doses but then taper off,” she said.

“So if people are able to stick with it, they may find their symptoms decrease over time.”

However, sometimes the side effects are so severe that some people can’t tolerate them long enough to see them lessen, she said. It seems Schumer may have had that experience with Wegovy.

Coping with side effects of GLP-1 drugs

In addition to gradually titrating up, clinicians have suggested other strategies to help patients stick with their medication until they adjust to the side effects.

In a July 2021 article published in Postgraduate Medicine, the authors stated that smaller, more frequent meals can help ease digestive woes while taking GLP-1 medications.

The authors wrote that avoiding fatty or spicy foods could help combat nausea. They noted that sufficient water and fiber intake could help mitigate constipation.

The article further emphasized the importance of educating people about the potential for side effects, which could help manage expectations and make it easier to continue the medication until side effects begin to ease up.

What if a weight loss drug isn’t working for you?

Trista Best, MPH, RDN, LD, a registered dietitian with Balance One Supplements, said that if people are having difficulty with a particular weight loss drug, several options can be tried.

“If a medication isn’t effective, options include adjusting the dosage, switching to a different weight loss drug, or exploring alternative treatments such as metabolic testing, personalized nutrition plans, or behavioral therapy,” Best told Healthline.

Best noted that doctors could also recommend other GLP-1 drugs such as liraglutide (Victoza, Saxenda) or even explore weight loss drugs that work through different mechanisms like phentermine, bupropion, or naltrexone.

Garcia-Webb added, however, that these alternative medications may not be as effective as GLP-1s. “[But] for some people, especially those who can’t tolerate the GI side effects, they may be a better fit,” she said.

Garcia-Webb said it’s also important to define what people mean when they say that their medication isn’t working for them.

“If it’s a question of side effects, many times lowering the dose, titrating up very slowly, and adding medications to help with the side effects can help quite a lot,” she said.

What Schumer’s experience highlights about weight loss drugs

Schumer’s different experiences with Wegovy and Mounjaro highlight the individualized nature of weight loss medications.

While GLP-1 drugs can be effective, tolerance varies widely, and finding the right fit may require adjustments or alternative treatments.

For those struggling with side effects, strategies like gradual dose increases, dietary modifications, and patient education can help.

As the landscape of obesity treatment continues to evolve, Schumer’s candid discussion reminds us that weight loss journeys are personal and that keeping it real can help others navigate their own paths.

Ricki Lake’s journey with hair loss is a story of resilience, vulnerability,…

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• Actor, director, and producer Elizabeth Banks shares how she prioritizes her health in her 50s.
• The “Hunger Games” actress is spreading awareness about preventing respiratory conditions like RSV, flu, and pneumococcal pneumonia.
• Banks shares her journey with healthy aging and how she’s navigated shingles and perimenopause.

Known for her iconic role in the “Hunger Games” franchise and Emmy-nominated part in “30 Rock,” actress Elizabeth Banks knows how to captivate an audience.

At 51, she’s using her platform to connect with Gen Xers about living healthily into their 50s.

A few years ago, before she turned 50, Banks contracted shingles, a viral infection caused by the varicella-zoster virus, which also causes chickenpox. Shingles typically cause a painful, blistering rash.

“I was misdiagnosed at first because I was a little young to be getting shingles, or so I was told. My symptoms included the classic stuff like a one-sided rash and tingling at the top of my head. I couldn’t sleep and experienced other symptoms, including a burning sensation,” Banks told Healthline.

Shingles was the only medical issue that ever resulted in Banks missing work.

“Suddenly, I felt a little bit my age, and my sense of invincibility was shattered. I felt I needed to take better care of myself in all aspects,” said Banks.

“Shingles is often brought on by stress, and I felt like my body was less able to handle stress, which I’ve lived with forever. I like being stressed out. I like doing a lot of things. And suddenly, I felt like, ‘Oh, I must check myself and look after myself better.’”

She learned that the Centers for Disease Control and Prevention (CDC) recommends the shingles vaccine for those 50 and older.

“There is a shingles-specific vaccine that is offered when you turn 50, or after you turn 19 if you are immunocompromised. It’s important to vaccinate against shingles to keep you safe and healthy,” Jen Brull, MD, president of the Board of Directors at the American Academy of Family Physicians, told Healthline.

While Banks said she always follows her doctor’s recommendations for vaccinations, she has become more diligent about staying up to date on vaccinations, including the flu shot, since experiencing shingles.

She recently partnered with Pfizer to spread awareness about respiratory vaccinations for flu, COVID-19, respiratory syncytial virus (RSV), and pneumococcal pneumonia. Visitors to VaxAssist.com can schedule a vaccination appointment and learn more about each vaccine.

“Staying on top of preventive health as we age is critical — it can make the difference between catching something early or dealing with a challenging diagnosis later in life once a condition has progressed,” said Brull.

Brull noted preventive services include vaccinations, cancer screenings like mammograms and colonoscopies, bloodwork, annual wellness exams and tests, and guidance on lifestyle factors like nutrition, exercise, and mental healthcare. 

“No matter your age, having a baseline is important. Think of all the things that happen when you get a regular checkup — that’s preventive care,” Brull said.

Healthline recently spoke with Banks to learn more about the importance of midlife vaccinations and how she prioritizes her health in her 50s.

This interview has been edited and condensed for clarity and length.

What should Gen Xers know about prioritizing their health?

Banks: I think Gen X is in a precarious spot because we have more access to information about our health and longevity than ever before, but we are also dealing with a lot.

For many of us, we’ve got young kids or teenagers in the house. We’ve got aging parents that we’re dealing with. We’ve got jobs which we’ve worked hard for. I feel like all those stress levels can often make our health not a priority because we have so much else going on.

My real advice is just a reminder to Gen X to look out for themselves too and take care of their health so that they can be there for their families, young and old, and continue excelling in their careers without getting sick.

How have you taken care of your health in your 50s?

Banks: I started by looking at my daily habits, particularly my diet and sleep. I’m also experiencing perimenopause, which all Gen X women are going through or are going to go through. That has brought changes in my body that I have to pay attention to.

I do a better job with my diet. I do a better job with exercise. I do a better job prioritizing walking. I do a better job getting enough sleep and lowering stress.

On top of that, I am getting vaccinated and keeping up with preventative health measures. I get my mammograms and my colonoscopies, all the fun stuff.

I came to realize that when you’re 50 or older, you’re more than six times greater risk of contracting pneumococcal pneumonia. Knowing that made me realize there’s a real midlife moment where we have to start paying a little bit better attention so that we can be around as long as possible.

How do you feel about experiencing perimenopause?

Banks: Perimenopause is happening to me, and menopause is just around the corner. I wish it was coming sooner, to be honest. I’d like to be through this patch of it.

I found that I had to pay closer attention to minor changes. I didn’t feel like myself, and so it was a bit of a wake-up call.

There will be some physical changes happening, and you’re not going to be the same. I ask, “What does that look like going forward?” I loved the opportunity it gave me to analyze my life and prioritize my health.

What to know about menopause

Menopause is a phase in which menstruation is absent for 12 months. The average age of onset for females is in the early 50s, though it can occur earlier or later.

“Menopause is a gradual process that can take several years and can have physical and emotional impacts,” said Brull.

Perimenopause, meanwhile, is a transitory phase before menopause that can last for a decade or more. This phase is typically when the classic menopausal symptoms begin.

Brull said healthy habits that can help women through the process include:

• moving your body regularly
• eating a healthy diet
• avoiding alcohol
• staying up to date on vaccinations and preventive care

“Some people find that cutting back on alcohol and caffeine helps manage the sleep changes that come with menopause. Others find that hormone replacement therapy (HRT) is the best way to manage their symptoms,” said Brull.

“There is no one-size-fits-all approach, but keeping healthy habits [is] a great way to ensure you’re doing what is in your control to stay well.”

If you notice that your periods become less regular, you feel more tired, experience hot flashes, or feel pain during intercourse, reach out to your doctor.

In addition to medical care, Brull said hearing other women’s experiences like Banks’ and maintaining a strong social community during menopause is impactful.  

“Identifying others in your life who have gone through menopause or are currently experiencing it can help make the experience less isolating,” she said. “If needed, your family doctor can help you find an online or local support group to join.”

We introduce the new campaign to Keep Antibiotics Working, fronted by our mascot Andi Biotic, and look at why we all need to be more aware of Antimicrobial Resistance (AMR).

• New research shows that weekend warriors, people who exercise just one or two days per week, have a lower risk of death than regular exercisers.
• Prior studies have also shown that weekend warriors achieve similar benefits to heart and brain health.
• Experts agree that when you exercise each week matters less than making sure you get enough.

A growing body of evidence shows that “weekend warriors” — people who concentrate their exercise into one or two days per week — experience the same health benefits as daily exercisers.

Physical activity guidelines for adults recommend at least 150 minutes of moderate-intensity exercise each week. While conventional wisdom suggests spreading this activity throughout the week, this approach doesn’t suit everyone’s lifestyle.

Enter the weekend warriors who hit their exercise goals in one or two days, typically on weekends. This consolidated approach to exercise has raised questions about its effects on health and longevity.

However, research increasingly demonstrates it’s the volume of exercise (hitting that minimum of 150 minutes), not the pattern, that determines the benefits.

Prior studies have linked weekend warrior workouts with comparable brain health and cardiovascular benefits as regular exercisers.

A new study published April 2 in the Journal of the American Heart Association (JAHA) provides substantial evidence supporting this approach.

The results show that compared to physically inactive individuals (those not meeting minimum recommended exercise guidelines), weekend warriors experienced mortality benefits comparable to those who exercised regularly throughout the week.

Both weekend warriors and regularly active individuals showed significantly lower risks of death from all causes, including cardiovascular disease and cancer. Notably, this research marks the first analysis to examine the relationship between physical activity patterns measured by fitness trackers and mortality outcomes.

Brad Donohue, PhD, a professor of psychology and creator of The Optimum Performance Program in Sports (TOPPS) at the University of Nevada Las Vegas, told Healthline the findings were “some of the best evidence we have seen so far” to support the weekend warrior exercise pattern. Donohue wasn’t involved in the study.

Weekend warriors have 26% lower risk of all-cause mortality

Researchers analyzed health and exercise data from more than 93,000 participants in the UK Biobank, a comprehensive biomedical database, to investigate potential associations between exercise patterns and mortality risk.

The study cohort was predominantly white (97%) with an average age of 62 years old; women comprised slightly more than half (56%) of participants.

To be included in the study, participants needed a complete seven-day record of physical activity captured by wearable fitness trackers — a method that typically provides more reliable data than self-reported exercise habits.

The trackers, which utilized machine learning, could detect and classify various physical activities, from bicycling to dancing.

Participants were then divided into three distinct groups based on their activity levels:

• Active regular — people who hit the minimum recommended 150 minutes of weekly physical activity throughout the week.
• Weekend warriors — people who hit the minimum recommended 150 minutes of weekly physical activity in one or two days.
• Inactive — people who did not hit the minimum recommended 150 minutes of weekly physical activity.

Over roughly eight years of follow up, both active groups experienced significantly less mortality risk than sedentary participants. 

“These findings send an important message that all movement counts. Many people struggle to fit in daily exercise during the work week, but this research shows that even if you can only be active on the weekends, you can still gain meaningful health benefits,” said Keith Diaz, PhD, an associate professor of behavioral medicine at Columbia University Medical Center and member of the AHA’s Physical Activity Science Committee, not involved in the study, told Healthline.

When compared to the inactive group, people who exercised throughout the week had a lower risk of death from all causes (26% lower), cardiovascular disease (24% lower), and cancer (13% lower).

Surprisingly, the protective benefits were even greater among the weekend warrior group — a result the study authors had not anticipated.

Weekend warriors had a 32% lower risk of death from all causes, a 31% lower risk of death from cardiovascular disease, and a 21% lower risk of death from cancer. 

However, there was no significant difference in risk when comparing both active groups.

“Neither approach was superior to the other. So, if you’re already active during the week, there’s no need to switch to a weekend-only routine. What matters most is meeting the recommended amount of physical activity in a way that fits your lifestyle,” said Diaz.

How to become a weekend warrior

Donohue told Healthline that the latest research on weekend warriors is “inspiring”, as it could encourage more people who might otherwise struggle to find time for exercise during the week.

One of the clear messages about the weekend warrior phenomenon is that everyone’s lifestyle may vary, so finding a personal strategy to meet minimum physical activity goals is essential.

“Weekend warrior workouts can take many forms. The best ones are those you enjoy and can stick with. For beginners or those returning to working out, something as simple as a long walk, leisurely bike ride, going for a hike at a local park, or doing some yard work or gardening can provide health benefits,” said Diaz.

Other options for individuals with higher fitness levels include:

• running
• pickup basketball
• amateur sports leagues
• fitness classes

Consistency is key, though, just like anything else. Donohue pointed out that one of the biggest motivators for fitness is social connection.

“If you want to increase the likelihood that you’re going to maintain regular exercise, establish a relationship with someone who is going to do it with you,” he said.

• Legendary actor Val Kilmer of ‘Top Gun’ fame passed away at 65 at his Los Angeles home.
• Kilmer’s daughter shared that the cause was pneumonia, an infectious disease of the lungs.
• Experts say Kilmer’s previous treatment for throat cancer and his age may have been contributing factors.
• It’s recommended that older adults protect their health by getting regular vaccinations, particularly against pneumonia.

Actor Val Kilmer, perhaps best known for his role as Tom “Iceman” Kazansky in the films “Top Gun” and “Top Gun: Maverick,” has died at 65.

Kilmer’s daughter, Mercedes Kilmer, announced her father had died of pneumonia on April 1 at his Los Angeles home.

Pneumonia is a lung infection caused by bacteria, viruses, or fungi that inflame the air sacs in the lungs, causing them to fill with pus or fluid. Symptoms generally include fever, chills, coughing, and problems with breathing.

This potentially fatal condition is most dangerous for infants and young children, people with weakened immune systems and other health problems, and adults ages 65 and older.

Kilmer previously battled with throat cancer in 2014. However, his daughter told The New York Times he had recovered from the disease.

Kilmer’s throat cancer, age were risk factors for pneumonia

Emma Lin, MD, a board certified pulmonologist, sleep medicine specialist, and co-founder of ReadyO2.com, explained to Healthline that Kilmer’s previous cancer battle, as well as his age, may have left him more prone to pneumonia.

“Many patients I’ve had who’ve survived throat cancer come to me with lung issues later on,” she said.

Lin added that radiation therapies used to treat throat cancer can weaken a person’s lungs, making infections like pneumonia more likely to develop.

“I always remember this when working with patients who’ve had cancer in the past,” she said. “Although they may appear well, their lungs will be weaker than normal.”

William Schaffner, MD, professor of preventive medicine and health policy and professor of medicine in infectious diseases at Vanderbilt University School of Medicine, said that, in general, people with throat cancer have a more difficult time clearing their mouth and throat.

“The secretions can be aspirated, that is, ‘go down the wrong tube’ into their airway — the bronchial tubes,” he told Healthline.

When these secretions make their way into the lungs, it can lead to inflammation and what is known as “aspiration pneumonia,” Schaffner explained.

Lin noted that increasing age is associated with a greater risk for pneumonia.

“I see a great many patients, particularly elderly patients, who are vulnerable to catching pneumonia,” she said.

Lin explained pneumonia can be more harmful to older individuals because their immune systems may not be as effective at eliminating infections as when they were younger.

What older adults can do to prevent pneumonia

Olalekan Otulana, MD, a general practitioner with Cassiobury Court, strongly recommends keeping up to date with your vaccinations.

“That includes the pneumococcal vaccine and the annual flu jab,” Otulana told Healthline, noting that vaccines may significantly reduce the risk of severe illness.

“Maintaining good overall health also plays a big role,” he added. “Stopping smoking, staying active, eating well, and managing chronic conditions if present (e.g., diabetes [or] heart disease) all help keep the immune system strong and lungs functioning well.”

Lin spoke of the importance of practicing good hygiene to prevent the spread of infections.

“It also helps if they keep their hands clean by washing them frequently as well as avoiding close contact with people who are ill,” she said.

For people with long-term health conditions such as asthma, chronic obstructive pulmonary disease (COPD), or heart disease, it’s crucial to follow your doctor’s advice, Lin said.

“It may involve regular use of inhalers or other medicines as prescribed by your doctor,” she noted.

Lin further advised that older adults remain active. “I explain to my patients that a short walk each day keeps the lungs functioning properly and builds a strong immune system,” she said.

Finally, Lin suggests making sure you get adequate sleep. “Sleep allows the body to heal and recover from infections,” she said.

According to the National Institute on Aging (NIH), adults over 65 need about 7–9 hours of sleep per night.

What we can learn from Kilmer’s passing

Kilmer’s death highlights the serious risks of pneumonia, especially to older adults and those with a history of illness.

While his talents on screen made him a beloved Hollywood icon, his health journey and battle with cancer highlight the importance of pneumonia prevention, which may be supported through vaccinations and maintaining overall wellness.

As fans remember Kilmer for his legendary performances, health experts emphasize that simple steps, such as staying active and following medical advice, can help reduce the risk of pneumonia and other respiratory infections.

• The U.S. Supreme Court is deciding whether states can deny Medicaid funding to Planned Parenthood because the organization’s clinics perform abortions.
• The Trump administration has also temporarily frozen $27 million in Title X family planning funding designated for Planned Parenthood.
• Experts say these funding reductions would reduce the health services provided by the organization, most impacting lower-income households and people in rural areas.

The U.S. Supreme Court is deliberating over whether states have the right to deny Medicaid reimbursement funding to Planned Parenthood.

The high court heard legal arguments on April 2 in a case stemming from South Carolina, where state leaders have decreed that Planned Parenthood should not receive Medicaid funding for any of its array of health services because abortions are performed at its clinics.

The justices are expected to announce their decision in the case as early as June. For now, the court appears divided over the issue, according to the Associated Press.

The question before the court is a technical one. It centers on whether a Medicaid recipient can sue over the right to choose their own healthcare provider.

However, experts say a ruling in favor of South Carolina would limit the healthcare choices of people on Medicaid. Many of those patients say it can be difficult to find a healthcare professional outside of Planned Parenthood that accepts Medicaid.

 “The Supreme Court is about to decide whether or not people who use Medicaid can fight against politically-driven, illegally-driven policies that want to take away access to their right to use government-based insurance to decide which provider they want to have,” said Alexis McGill Johnson, president and chief executive officer of the Planned Parenthood Federation of America, on Crooked Media’s “What a Day” podcast in a statement.

The court hearing came just days after the Trump administration announced it is withholding tens of millions of dollars in Title X funding from Planned Parenthood as it looks into whether the organization is violating federal civil rights laws and President Donald Trump’s executive orders.

Experts said the court ruling and the Title X decision could have far-reaching consequences.

“The impacts could be significant,” Therea Cheng, MD, an assistant clinical professor of emergency medicine at the University of California San Francisco, told Healthline. “Planned Parenthood is a lifeline to basic reproductive health for many low-income people.”

“Continuing to defund the work of women’s health supporters like Planned Parenthood is dangerous and leaves millions of people without resources,” Cynthia Plotch, co-founder of the women’s health products company Winx Health, told Healthline. “Now more than ever, it’s critical we continue fighting for education, resources, and solutions.”

Medicaid and Planned Parenthood

Since 1977, the Hyde Amendment approved by Congress has prohibited the use of federal funds to pay for abortion services, with only a few exceptions.

According to Planned Parenthood’s most recent annual report, there were 392,000 abortions performed at the organization’s nearly 600 health centers in 2023.

That was out of more than 9 million overall health services provided to 2 million people. Among the services were more than 4 million tests and treatments for sexually transmitted infections (STIs), and more than 2 million services involving birth control. There were also more than 400,000 pap smears and breast exams.

In addition, more than 1 million people used Planned Parenthood as a resource for education, programming, outreach, and training.

About 34% of Planned Parenthood’s revenues, nearly $700 million, comes from funding such as Medicaid, government grants, and contracts.

Experts say denying Medicaid funding to Planned Parenthood reduces all the health services the organization offers and limits the options for the lower-income households the federal program covers.

“This is creating a possible restriction of access for many patients for services that have nothing to do with abortion,” Lisa Valle, DO, OB-GYN and medical director of Oasis Women’s Sexual Function Center in Santa Monica, CA, told Healthline.

“People turn to Planned Parenthood… not only for reproductive care but also for lifesaving cancer screenings,” added Plotch.

“Defunding access will hurt our communities, leaving many without options. The reality is stark: when women don’t know their options, they can’t access them. We’ve seen firsthand what happens when women’s health is relegated to whispers behind closed doors.”

Planned Parenthood and Title X funds

Title X has provided funding for family planning programs for more than 50 years.

Among the services it funds are birth control, pregnancy testing, assistance for becoming pregnant, and infertility services.

The Trump administration has temporarily frozen $27 million in Title X funds to Planned Parenthood due to “possible violations” of executive orders that prohibited promotions based on diversity, equity, and inclusion as well as “taxpayer subsidization of open borders.”

The Department of Health and Human Services (HHS) has given Planned Parenthood 10 days to respond to the allegations.

Experts say this reduction in funding could have a wide range of impacts.

“It’s endangering the health and welfare of families across the country,” said Cheng. “It’s creating chaos for providers and patients.”

“Planned Parenthood is the only source of healthcare for patients who can’t get healthcare elsewhere,” noted Valle.

“Title X funding supports critical healthcare services, like cervical and breast cancer screenings, STI testing and treatment, and HIV services. Clinics that rely on these funds may have to cut back on preventive care, potentially leading to higher rates of undiagnosed conditions,” said Plotch.

“Simply put, the reduction of Title X funding poses a serious threat to reproductive health care access, particularly for low-income women, rural communities, and marginalized groups,” she added. “This will lead to worse health outcomes, increased unintended pregnancies, and greater health disparities across the country. We deserve better.”

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